An 18-year-old man and 35-year-old woman, both of San Jose, were killed in separate incidents over the weekend. Their deaths marked the city’s 21st and 22nd homicides this year, respectively. There were 20 homicides in San Jose in all of 2010.

Melissa Ross died in a Saturday night shooting, according to police. She was found in the driver’s seat of a black Mercedes sedan in the 4000 block of Ambler Way at about 10:30 p.m., Officer Jose Garcia said. It appeared that Ross had been shot in the car.

Richard Herrera, 20, of San Jose, a relative of Ross, arrived at Santa Clara Valley Medical Center at 11 p.m. with gunshot wounds that were not life threatening, Garcia said. He was treated and released at the hospital.

Herrera was in the passenger seat of the car at the time of the shooting, investigators said.

No arrests have been made. It is unknown if the suspect, or suspects, targeted Ross, Herrera or both, Garcia said.

Police say the Ross shooting is not connected to the stabbing of San Jose resident Vincent Tran Le, 18, in the 1700 block of Schulte Drive earlier Saturday morning. Officers found Le at about 4 a.m. in the 1700 block of Schulte Drive. He was taken to Regional Medical Center in San Jose and pronounced dead a few hours later.

An investigation revealed Le was stabbed during an altercation between two local rival gangs. Gang-related slogans and hand gestures were exchanged, witnesses told police, during and before the altercation.

Police believe Le was friends with members of one of the involved gangs. The degree of his involvement remains under investigation.

The investigation also reveled Le had been stabbed during a similar gang-related altercation May 1 in the same area as this more recent stabbing took place.

It is unknown whether Le was targeted. The motive for the altercation remains under investigation. No arrests have been made.

Anyone with information about the incident is asked to call Detective Sgt. Rafael Nieves or Detective Glenn Albin in the San Jose police homicide unit at (408) 277-5283.